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skip to content shop cart / $ 0.00 no products in the cart. login / register alivebynature articles nmn nad+ nad+ research & news nicotinamide riboside berberine green tea boswellia lycopene coq10 omega 3 oils curcumin exercise high intensity interval training cardio weight training yoga nutrition & diet foods weight loss fasting aging research aging news about us privacy policy return policies shipping policies terms and conditions cart no products in the cart. checkout + about nmn nmn has been shown to be effective in research with micein combatting nearly all age related disease such as parkinson’s, alzheimers, heart disease diabetes, cancer, and more. one area where it has shown the strongest effect in mice is reversing sarcopenia (muscle wasting), in older subjects. dr sinclair’s most recent research gave nmn to old micefor 2 months and found their strength and endurance nearly doubled ( r ).examination of their muscles showed they were indistinguishable from those of young mice.they also grew new blood vessels and vastly increased capillary density. researchers are hopeful that the same results will apply to humans, but 2 months in mice is equivalent to several years in humans.the longer lifespanand understandable caution in research with humans means it will be years, if not decades, before it is proven. for human usage, it has been available for purchase as a dietary supplementfor a few years now.however, recent studies have shown that oral supplements of nmn such as capsules are digested in the stomach and very little of the nmn makes it’s way to the bloodstream ( r ). sublingual delivery of nmn can bypass the digestive system and deliver nmn directly to the bloodstream. alivebynature has been the dominantseller of nmn over the last year.from speaking with customers we have discovered that multiple sublingual dosages throughout the day dramatically increases the effectiveness of nmn. using our protocol of frequent doses of nmn taken sublingually, we have seen the same restoration of muscle strength and endurance as the mice in dr sinclair’s research, in a very short time.my personal experience has been a return to the strength and fitness of my 20’s in just 3 months.even more shocking, i have experienced muscle growth that is beyond what i ever had in my 20’s.i am convinced this delivery method and frequencydoes more than just restore skeletal muscle to youthful levels – it actually increases muscle beyond the “normal” youthful levels. older athletes needed – $20,000 cash and prizes my results december 2017 not bad for 57 year old (i thought) june 21 2018 after 3 months taking sublingual nmn at 57 years old, i felt i was in pretty good shape from running, swimming or lifting weights 5-6 days a week. yes, knee, hip, back and shoulder pains limited to how much i could run or lift. i was slower and weaker than when i was young, but who isn’t? at 58 years old, i am back to running a 6 minute mile, lifting the heavier weights and carrying around more muscle than i had in my 20’s. most amazing is, the improvements came from less than 3 months of taking frequent doses of sublingual nmn (under the tongue). my personal experience has been that taking frequent doses of nmn sublingually (under the tongue) greatly improves the effectiveness. click here to read more older athletes needed – $20,000 cash and prizes the problem with capsules the problem with capsules – digested in stomach it has also long been suspected that most nr is digested to nam in the gastro-intestinal tract intact ( r ). more recently, this research published in 2018 confirms that most oral supplements of nmn and nr are digested to nam in the gi tract or the liver. future pharmacological and nutraceutical efforts to boost nad will need to take into account the minimal oral bioavailability of nr and nmn ( r ) we also showed that intravenous, but not oral administration of nr or nmn delivered intact molecules to multiple tissues ( r ) unlike in cell culture where nr and nmn are readily incorporated into nad, oral administration fails to deliver nr or nmn to tissues ( r ) interestingly, we found that neither compound was able to enter the circulation intact in substantial quantities when delivered orally ( r ) the most recent studies showing tremendous health benefits with nmn were accomplished by feeding mice very large dosages of nmn in water ( r ). however the dosage of 300-400 mg per kg of bodyweight used in many of these studies would equate to approximately 2,000 mg per day for a 70 kg human. a more effective delivery method is needed ! [accordion-item_inner title=”sublingual vs capsules”] [/accordion-item_inner] sublingual vs capsules sublingual (under the tongue) delivery can provide rapid absorption via the blood vessels under the tongue rather than via the digestive tract. ( r , r ) the absorption of the different molecules delivered through the sublingual route can be 3 to 10 times greater than oral route and is only surpassed by direct iv injection ( r ). sublingual can be more bioavailable than injection ! with intraperitoneal injection, the primary route of absorption is via the mesenteric vessels, which drain into the portal vein and pass through the liver before reaching the bloodstream. this means, ip avoids the gi tract, but is still sent directly to the liver, where much of it is converted to nad+. elevated nad+ in the liver is good, but its far better to reach the bloodstream with intact nmn. sublingual delivery is not filtered by the liver and can reach systemic circulation intact, so can actually result in greater bioavailability that direct injection! some examples are: a sublingual formulation of zol… exhibited a faster rate of absorption and higher drug exposure as compared to subcutaneous injection ( r ) sublingually administered epin… results in more rapid absorption and a higher peak plasma concentration compared to injected epin… .( r ) 40mg of sublingually administered pir.. was found to be as effective as a 75 mg intramuscular injection of dicl… ( r ) nmn perfect for sublingual depending on the molecule, sublingual delivery can substantially improve the speed and bioavailability. smaller molecules that are hydrophilic such as nmn are well-suited. a drug which has been formulated for sublingual should ideally have a molecular weight of less than 500 ( r ) nmn is very hydrophilic, with a molecular weight of 324, making it a perfect fit for sublingual delivery. dosage and frequency short window for maximum availability the chart at right is from the 2016 mills study with mice given 300 mg/kg of bodyweight by oral gavage. it clearly shows nmn is found in blood plasma within minutes, peaking at around 15 minutes. after that, nmn drops rapidly in blood, and appears as increased nad+ in the liver. of course this is in mice, and humans have a slower response, but we believe it is during the short time period when nmn is available in the bloodstream and can reach tissues throughout the body that the real benefits occur. frequency – how often to take nearly all research on mice and humans using nr and nmn is focused on measuring nad+ and the various metabolites in the liver as it is the primary supplier of nad+ throughout the body ( r ). if elevating nad+ in the liver is the goal, 1-2 larger dosages per day seem to be sufficient to achieve the maximum increase in liver nad+ (r). outside the liver however, we believe supplying nmn directly to the bloodstream is more effective at increasing nad+ not just in the liver, but throughout the body. smaller, more frequent dosages based on the short window that exogenous nmn is available in the bloodstream before being filtered out by the liver, we believe smaller, more frequent dosages are likely more effective than 1-2 larger dosages. using this philosophy, many of our customers have been reporting more perceived benefit from more frequent intake, with many taking 6-12 times per day. we recommend taking 4-8 times

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Domain Name: ALIVEBYNATURE.COM
Registry Domain ID: 1554568443_DOMAIN_COM-VRSN
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Name Server: CARL.NS.CLOUDFLARE.COM
Name Server: JEAN.NS.CLOUDFLARE.COM
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  ARGS domain =alivebynature.com

  PORT 43

  TYPE domain
RegrInfo
DOMAIN

  NAME alivebynature.com

  CHANGED 2017-04-06

  CREATED 2009-05-05

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  CARL.NS.CLOUDFLARE.COM 173.245.59.106

  JEAN.NS.CLOUDFLARE.COM 173.245.58.121

  REGISTERED yes

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